BamE structure: the assembly of β-barrel proteins in the outer membranes of bacteria and mitochondria.
نویسندگان
چکیده
منابع مشابه
Assembly of the β-Barrel Outer Membrane Proteins in Gram-Negative Bacteria, Mitochondria, and Chloroplasts
In the last decade, there has been an explosion of publications on the assembly of β-barrel outer membrane proteins (OMPs), which carry out diverse cellular functions, including solute transport, protein secretion, and assembly of protein and lipid components of the outer membrane. Of the three outer membrane model systems-Gram-negative bacteria, mitochondria and chloroplasts-research on bacter...
متن کاملThe -Barrel Outer Membrane Protein Assembly Complex of Neisseria meningitidis
The evolutionarily conserved protein Omp85 is required for outer membrane protein (OMP) assembly in gram-negative bacteria and in mitochondria. Its Escherichia coli homolog, designated BamA, functions with four accessory lipoproteins, BamB, BamC, BamD, and BamE, together forming the -barrel assembly machinery (Bam). Here, we addressed the composition of this machinery and the function of its co...
متن کاملStructure and function of BamE within the outer membrane and the β-barrel assembly machine.
Insertion of folded proteins into the outer membrane of Gram-negative bacteria is mediated by the essential β-barrel assembly machine (Bam). Here, we report the native structure and mechanism of a core component of this complex, BamE, and show that it is exclusively monomeric in its native environment of the periplasm, but is able to adopt a distinct dimeric conformation in the cytoplasm. BamE ...
متن کاملβ-Barrel membrane protein assembly by the Bam complex.
β-barrel membrane proteins perform important functions in the outer membranes (OMs) of Gram-negative bacteria and of the mitochondria and chloroplasts of eukaryotes. The protein complexes that assemble these proteins in their respective membranes have been identified and shown to contain a component that has been conserved from bacteria to humans. β-barrel proteins are handled differently from ...
متن کاملBiogenesis and folding of β-barrel membrane proteins
β-barrel membrane proteins are composed of multiple antiparallel β-strands and form pores in the outer membranes of endosymbiotic organelles like mitochondria and the evolutionary related Gramnegative bacteria. These β-barrel channels are crucial for signal transduction, metabolite transport, and protein translocation. How are β-barrel membrane proteins assembled into the outer membrane? After ...
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ورودعنوان ژورنال:
- EMBO reports
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2011